1. The sterile Berkefeld filtrates of broth cultures of certain strains of Staphylococcus aureus have a selective poisonous action for the skin of rabbits.

2. The poison is thermolabile, being completely destroyed when heated to 55°C for 1 hour.

3. The poison when injected intradermally into rabbits stimulates the production of antitoxin. We therefore conclude that the poison is a soluble toxin.

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