The isolation in pure culture of a definite morphological entity (vibrio or spirillum) with practically the same biological characters from a series of cases of the same clinical complex (abortion) establishes a presumption in favor of the specific identity of the organisms and also in favor of the inference that such organisms are etiologically related to the diseased condition. This presumption is strengthened by the fact that disease of the fetal membranes followed the injection of pure cultures of this organism in two out of four cases.

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