1. A single small dose of ethylhydrocuprein (optochin base), which by itself has practically no protective effect against experimental pneumococcal infection in mice, is capable of increasing the threshold value of the type homologous antipneumococcus serum at least fifty times.

2. This effect is proportionately many times greater than a simple summation of the protective effects of these two bodies.

3. No such effect is obtained when the antiserum used is one produced against a strain of pneumococcus from a group other than that to which the infecting pneumococcus belongs.

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