During the first four or five days after ligation of the ureter, the changes in the kidney are mainly degenerative in type. One week after ligation of the ureter connective tissue cells begin to appear infiltrating the kidney tissues. There is also an increase in the vascular cells of the glomeruli. These changes are well marked at the end of twenty days from the time of ligation. At the end of twenty days from the time of ligation there is also a marked hypertrophy of the control kidney, the glomeruli showing an average increase in size of twenty-five microns.

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