Our studies give evidence of increase in the iron elimination in three of five dogs during a period of two weeks following splenectomy, but not in two other dogs. The occasional increased output of iron may have some relation to the anemia which occurs in the early weeks after splenectomy and which varies in degree in different animals.

No evidence was secured of an increase in the iron output at 1, 9, and 20 months after splenectomy.

From our own studies and from examination of the literature of the subject, we conclude that the spleen does not exercise a constant and important influence upon the iron metabolism of the body.

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