Ultraviolet A (UVA) irradiation is effectively used to treat patients with atopic dermatitis and other T cell mediated, inflammatory skin diseases. In the present study, successful phototherapy of atopic dermatitis was found to result from UVA radiation-induced apoptosis in skin-infiltrating T helper cells, leading to T cell depletion from eczematous skin. In vitro, UVA radiation-induced human T helper cell apoptosis was mediated through the FAS/FAS-ligand system, which was activated in irradiated T cells as a consequence of singlet oxygen generation. These studies demonstrate that singlet oxygen is a potent trigger for the induction of human T cell apoptosis. They also identify singlet oxygen generation as a fundamental mechanism of action operative in phototherapy.
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17 November 1997
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Brief Definitive Report|
November 17 1997
Evidence that Singlet Oxygen-induced Human T Helper Cell Apoptosis Is the Basic Mechanism of Ultraviolet-A Radiation Phototherapy
Akimichi Morita,
Akimichi Morita
From *Clinical and Experimental Photodermatology, Department of Dermatology, Heinrich-Heine-University of Düsseldorf, D-40225 Düsseldorf; ‡Department of Dermatology, Hannover Medical School, D-30625 Hannover; and §Institute of Physiological Chemistry I, Heinrich-Heine-University, D-40225 Düsseldorf, Germany
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Thomas Werfel,
Thomas Werfel
From *Clinical and Experimental Photodermatology, Department of Dermatology, Heinrich-Heine-University of Düsseldorf, D-40225 Düsseldorf; ‡Department of Dermatology, Hannover Medical School, D-30625 Hannover; and §Institute of Physiological Chemistry I, Heinrich-Heine-University, D-40225 Düsseldorf, Germany
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Helger Stege,
Helger Stege
From *Clinical and Experimental Photodermatology, Department of Dermatology, Heinrich-Heine-University of Düsseldorf, D-40225 Düsseldorf; ‡Department of Dermatology, Hannover Medical School, D-30625 Hannover; and §Institute of Physiological Chemistry I, Heinrich-Heine-University, D-40225 Düsseldorf, Germany
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Constanze Ahrens,
Constanze Ahrens
From *Clinical and Experimental Photodermatology, Department of Dermatology, Heinrich-Heine-University of Düsseldorf, D-40225 Düsseldorf; ‡Department of Dermatology, Hannover Medical School, D-30625 Hannover; and §Institute of Physiological Chemistry I, Heinrich-Heine-University, D-40225 Düsseldorf, Germany
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Karin Karmann,
Karin Karmann
From *Clinical and Experimental Photodermatology, Department of Dermatology, Heinrich-Heine-University of Düsseldorf, D-40225 Düsseldorf; ‡Department of Dermatology, Hannover Medical School, D-30625 Hannover; and §Institute of Physiological Chemistry I, Heinrich-Heine-University, D-40225 Düsseldorf, Germany
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Markus Grewe,
Markus Grewe
From *Clinical and Experimental Photodermatology, Department of Dermatology, Heinrich-Heine-University of Düsseldorf, D-40225 Düsseldorf; ‡Department of Dermatology, Hannover Medical School, D-30625 Hannover; and §Institute of Physiological Chemistry I, Heinrich-Heine-University, D-40225 Düsseldorf, Germany
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Susanne Grether-Beck,
Susanne Grether-Beck
From *Clinical and Experimental Photodermatology, Department of Dermatology, Heinrich-Heine-University of Düsseldorf, D-40225 Düsseldorf; ‡Department of Dermatology, Hannover Medical School, D-30625 Hannover; and §Institute of Physiological Chemistry I, Heinrich-Heine-University, D-40225 Düsseldorf, Germany
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Thomas Ruzicka,
Thomas Ruzicka
From *Clinical and Experimental Photodermatology, Department of Dermatology, Heinrich-Heine-University of Düsseldorf, D-40225 Düsseldorf; ‡Department of Dermatology, Hannover Medical School, D-30625 Hannover; and §Institute of Physiological Chemistry I, Heinrich-Heine-University, D-40225 Düsseldorf, Germany
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Alexander Kapp,
Alexander Kapp
From *Clinical and Experimental Photodermatology, Department of Dermatology, Heinrich-Heine-University of Düsseldorf, D-40225 Düsseldorf; ‡Department of Dermatology, Hannover Medical School, D-30625 Hannover; and §Institute of Physiological Chemistry I, Heinrich-Heine-University, D-40225 Düsseldorf, Germany
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Lars-Oliver Klotz,
Lars-Oliver Klotz
From *Clinical and Experimental Photodermatology, Department of Dermatology, Heinrich-Heine-University of Düsseldorf, D-40225 Düsseldorf; ‡Department of Dermatology, Hannover Medical School, D-30625 Hannover; and §Institute of Physiological Chemistry I, Heinrich-Heine-University, D-40225 Düsseldorf, Germany
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Helmut Sies,
Helmut Sies
From *Clinical and Experimental Photodermatology, Department of Dermatology, Heinrich-Heine-University of Düsseldorf, D-40225 Düsseldorf; ‡Department of Dermatology, Hannover Medical School, D-30625 Hannover; and §Institute of Physiological Chemistry I, Heinrich-Heine-University, D-40225 Düsseldorf, Germany
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Jean Krutmann
Jean Krutmann
From *Clinical and Experimental Photodermatology, Department of Dermatology, Heinrich-Heine-University of Düsseldorf, D-40225 Düsseldorf; ‡Department of Dermatology, Hannover Medical School, D-30625 Hannover; and §Institute of Physiological Chemistry I, Heinrich-Heine-University, D-40225 Düsseldorf, Germany
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Akimichi Morita
,
Thomas Werfel
,
Helger Stege
,
Constanze Ahrens
,
Karin Karmann
,
Markus Grewe
,
Susanne Grether-Beck
,
Thomas Ruzicka
,
Alexander Kapp
,
Lars-Oliver Klotz
,
Helmut Sies
,
Jean Krutmann
From *Clinical and Experimental Photodermatology, Department of Dermatology, Heinrich-Heine-University of Düsseldorf, D-40225 Düsseldorf; ‡Department of Dermatology, Hannover Medical School, D-30625 Hannover; and §Institute of Physiological Chemistry I, Heinrich-Heine-University, D-40225 Düsseldorf, Germany
Address correspondence to Prof. Dr. Jean Krutmann, Clinical and Experimental Photodermatology, Department of Dermatology, Heinrich-Heine-University Düsseldorf, Moorenstr. 5, D-40225 Düsseldorf. Phone: +49 211 8117627; FAX: +49 211 8118830; E-mail: [email protected]
Received:
May 23 1997
Revision Received:
August 18 1997
Online ISSN: 1540-9538
Print ISSN: 0022-1007
1997
J Exp Med (1997) 186 (10): 1763–1768.
Article history
Received:
May 23 1997
Revision Received:
August 18 1997
Citation
Akimichi Morita, Thomas Werfel, Helger Stege, Constanze Ahrens, Karin Karmann, Markus Grewe, Susanne Grether-Beck, Thomas Ruzicka, Alexander Kapp, Lars-Oliver Klotz, Helmut Sies, Jean Krutmann; Evidence that Singlet Oxygen-induced Human T Helper Cell Apoptosis Is the Basic Mechanism of Ultraviolet-A Radiation Phototherapy . J Exp Med 17 November 1997; 186 (10): 1763–1768. doi: https://doi.org/10.1084/jem.186.10.1763
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