Interleukin 7 (IL-7) stimulates the proliferation of B cell progenitors, thymocytes, and mature T cells through an interaction with a high affinity receptor (IL-7R) belonging to the hematopoietin receptor superfamily. We have further addressed the role of IL-7 and its receptor during B and T cell development by generating mice genetically deficient in IL-7R. Mutant mice display a profound reduction in thymic and peripheral lymphoid cellularity. Analyses of lymphoid progenitor populations in IL-7R-deficient mice define precisely those developmental stages affected by the mutation and reveal a critical role for IL-7R during early lymphoid development. Significantly, these studies indicate that the phase of thymocyte expansion occurring before the onset of T cell receptor gene rearrangement is critically dependent upon, and mediated by the high affinity receptor for IL-7.
Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.
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J J Peschon, P J Morrissey, K H Grabstein, F J Ramsdell, E Maraskovsky, B C Gliniak, L S Park, S F Ziegler, D E Williams, C B Ware, J D Meyer, B L Davison; Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.. J Exp Med 1 November 1994; 180 (5): 1955–1960. doi: https://doi.org/10.1084/jem.180.5.1955
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