Regulation of macrophage scavenger receptor (MSR) activity may be an important determinant of the extent of atherogenesis. The effect of macrophage-colony-stimulating factor (M-CSF) on this pathway was studied using a recently developed monoclonal antibody to murine MSR. M-CSF markedly and selectively increased MSR synthesis in murine macrophages: posttranslationally, the receptor appeared more stable and shifted to a predominantly surface distribution. Functionally, M-CSF enhanced modified lipoprotein uptake and increased divalent cation-independent adhesion in vitro. These results suggest a plausible mechanism whereby M-CSF production in the atheromatous plaque microenvironment could promote the recruitment and retention of mononuclear phagocytes and subsequent foam cell formation.
Macrophage-colony-stimulating factor selectively enhances macrophage scavenger receptor expression and function.
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W J de Villiers, I P Fraser, D A Hughes, A G Doyle, S Gordon; Macrophage-colony-stimulating factor selectively enhances macrophage scavenger receptor expression and function.. J Exp Med 1 August 1994; 180 (2): 705–709. doi: https://doi.org/10.1084/jem.180.2.705
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