The murine acquired immunodeficiency syndrome (MAIDS) caused by defective LP-BM5 murine leukemia virus (MuLV) is a disease that shows severe immunodeficiency with abnormal lymphoproliferation, and hypergammaglobulinemia in susceptible C57BL/6 (B6) mice. To examine the cellular mechanisms of development of MAIDS, we injected LP-BM5 MuLV intraperitoneally into B6 mice bearing the X chromosome-linked immunodeficiency (xid). xid mice lack functionally mature B cells including Ly-1 B cells (also known as B-1 cells). All B6 mice died by 20 wk after LP-BM5 MuLV inoculation. In marked contrast, xid mice have continued to survive without any sign of MAIDS-related symptoms till at least 20 wk after the inoculation. The delayed progression of MAIDS in xid mice appears to depend on xid mutation, according to our experiments using both sexes of (B6.xid x B6)F1 and (B6 x B6.xid)F1 mice. Furthermore, Ly-1 B cells, enriched by a FACS, were shown to integrate the defective genome and appeared to be a major virus-infected B cell population. Our data corroborate that Ly-1 B cells play an important role in the induction and progression of MAIDS.
Article|
March 01 1993
Delayed progression of a murine retrovirus-induced acquired immunodeficiency syndrome in X-linked immunodeficient mice.
Y Hitoshi,
Y Hitoshi
Department of Immunology, University of Tokyo, Japan.
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Y Okada,
Y Okada
Department of Immunology, University of Tokyo, Japan.
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E Sonoda,
E Sonoda
Department of Immunology, University of Tokyo, Japan.
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A Tominaga,
A Tominaga
Department of Immunology, University of Tokyo, Japan.
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M Makino,
M Makino
Department of Immunology, University of Tokyo, Japan.
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K Suzuki,
K Suzuki
Department of Immunology, University of Tokyo, Japan.
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J Kinoshita,
J Kinoshita
Department of Immunology, University of Tokyo, Japan.
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K Komuro,
K Komuro
Department of Immunology, University of Tokyo, Japan.
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T Mizuochi,
T Mizuochi
Department of Immunology, University of Tokyo, Japan.
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K Takatsu
K Takatsu
Department of Immunology, University of Tokyo, Japan.
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Y Hitoshi
Department of Immunology, University of Tokyo, Japan.
Y Okada
Department of Immunology, University of Tokyo, Japan.
E Sonoda
Department of Immunology, University of Tokyo, Japan.
A Tominaga
Department of Immunology, University of Tokyo, Japan.
M Makino
Department of Immunology, University of Tokyo, Japan.
K Suzuki
Department of Immunology, University of Tokyo, Japan.
J Kinoshita
Department of Immunology, University of Tokyo, Japan.
K Komuro
Department of Immunology, University of Tokyo, Japan.
T Mizuochi
Department of Immunology, University of Tokyo, Japan.
K Takatsu
Department of Immunology, University of Tokyo, Japan.
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1993) 177 (3): 621–626.
Citation
Y Hitoshi, Y Okada, E Sonoda, A Tominaga, M Makino, K Suzuki, J Kinoshita, K Komuro, T Mizuochi, K Takatsu; Delayed progression of a murine retrovirus-induced acquired immunodeficiency syndrome in X-linked immunodeficient mice.. J Exp Med 1 March 1993; 177 (3): 621–626. doi: https://doi.org/10.1084/jem.177.3.621
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