A synthetic tetrasaccharide structurally related to blood groups and selectin ligands inhibited division of astrocytes, gliomas, and neuroblastomas at micromolar concentrations. The compound was cytostatic for primary astrocytes in culture, but cytotoxic for fast proliferating cell lines.
Inhibition of proliferation of normal and transformed neural cells by blood group-related oligosaccharides.
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F F Santos-Benito, A Fernández-Mayoralas, M Martín-Lomas, M Nieto-Sampedro; Inhibition of proliferation of normal and transformed neural cells by blood group-related oligosaccharides.. J Exp Med 1 September 1992; 176 (3): 915–918. doi: https://doi.org/10.1084/jem.176.3.915
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