In mice double transgenic for functionally rearranged T cell receptor (TCR) V beta 2 and V beta 8.2 genes we found that most T lymphocytes express both TCR beta chains simultaneously. These T cells show no abnormality in thymic selection in vivo and their TCRs are capable of transducing activation signals in vitro. These results indicate that multispecific T cells may appear in the periphery if allelic exclusion of TCR beta genes is not established at the level of gene rearrangement.
Allelic exclusion at DNA rearrangement level is required to prevent coexpression of two distinct T cell receptor beta genes.
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J P van Meerwijk, P Romagnoli, A Iglesias, H Bluethmann, M Steinmetz; Allelic exclusion at DNA rearrangement level is required to prevent coexpression of two distinct T cell receptor beta genes.. J Exp Med 1 October 1991; 174 (4): 815–819. doi: https://doi.org/10.1084/jem.174.4.815
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