Depletion of CD4+ cells using anti-CD4 monoclonal antibodies leads to allograft tolerance. Here we show that anti-CD4-mediated tolerance to pancreatic islets of Langerhans transplanted from an A/J (IEk) donor to a diabetic C57B1/6 (B6) (IE-) recipient occurs in the absence of clonal deletion of the potentially IE-reactive V beta 11+ T cells. Instead, a state of clonal anergy is induced in both the CD4+V beta 11+ and CD8+V beta 11+ T cell subsets. This clonal anergy can be partially overcome in vitro by the addition of recombinant interleukin 2.
Anti-CD4 mediates clonal anergy during transplantation tolerance induction.
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S E Alters, J A Shizuru, J Ackerman, D Grossman, K B Seydel, C G Fathman; Anti-CD4 mediates clonal anergy during transplantation tolerance induction.. J Exp Med 1 February 1991; 173 (2): 491–494. doi: https://doi.org/10.1084/jem.173.2.491
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