A third allele at the DRB3 locus, DRw52c, represents an intermediate sequence between DRw52a and DRw52b and may have arisen by a gene conversion-like event. The recognition of cells bearing these molecules by a number of alloreactive and antigen-specific DR-restricted T cell clones was analyzed. On the basis of a theoretical model of HLA class II structure, distinct amino acid clusters have been identified as motifs controlling TCR recognition. These are located both in the cleft and in the alpha-helical edge of the MHC class II recognition platform. Motifs shared between two alleles may restrict public T cell clones.
Correlation of structure with T cell responses of the three members of the HLA-DRw52 allelic series.
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J Gorski, C Irle, E M Mickelson, M J Sheehy, A Termijtelen, C Ucla, B Mach; Correlation of structure with T cell responses of the three members of the HLA-DRw52 allelic series.. J Exp Med 1 September 1989; 170 (3): 1027–1032. doi: https://doi.org/10.1084/jem.170.3.1027
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