Lymphocytes isolated from human fetal liver and expanded in vitro in IL-2-containing media reveal the existence of CD4+ gamma, delta T cells. These cells display differential features of double-negative and CD8+ gamma, delta T cells as well as of CD4+ alpha, beta T cells. Thus, they failed to lyse targets in lectin-mediated killing assays and to perform classical helper functions. These results add new information necessary for a better understanding of the physiological role of the gamma, delta T cells.
Isolation and characterization of (gamma, delta) CD4+ T cell clones derived from human fetal liver cells.
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P Aparicio, J M Alonso, M L Toribio, M A Marcos, L Pezzi, C Martínez-A; Isolation and characterization of (gamma, delta) CD4+ T cell clones derived from human fetal liver cells.. J Exp Med 1 September 1989; 170 (3): 1009–1014. doi: https://doi.org/10.1084/jem.170.3.1009
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