We have previously shown that tobacco glycoprotein (TGP), a polyphenol-rich glycoprotein isolated from tobacco or from cigarette smoke, affects the immune system. In this study we show that TGP induces human PBL and adherent cells to produce IL-1 alpha and IL-1 beta. Two peaks of IL-1 activity were observed; one at 18-24 h, the second at 4-6 d after initiation of culture. A similar pattern was observed for the steady state level of IL-1 mRNA. These data suggest that the production of IL-1 by cells stimulated with TGP might be a factor in cardiovascular disease associated with cigarette smoking.
Two peaks of interleukin 1 expression in human leukocytes cultured with tobacco glycoprotein.
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T Francus, G Manzo, M Canki, L C Thompson, P Szabo; Two peaks of interleukin 1 expression in human leukocytes cultured with tobacco glycoprotein.. J Exp Med 1 July 1989; 170 (1): 327–332. doi: https://doi.org/10.1084/jem.170.1.327
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