A cDNA encoding a new human lymphocyte cell surface molecule has been isolated and shown to identify a fourth member of a recently discovered family of adhesion proteins. This lymphocyte-associated molecule (LAM-1) is uniquely composed of multiple distinct domains, one domain homologous with animal lectins, one homologous with epidermal growth factor, and two short consensus repeat units similar to those found in C3/C4 binding proteins. This cDNA clone hybridized with RNAs found in B cell lines and T lymphocytes, but not with RNA from other cell types. The amino acid sequence of LAM-1 is 77% homologous with the sequence of the mouse lymphocyte homing receptor, suggesting that LAM-1 may function in human lymphocyte adhesion. The LAM-1 gene is located on chromosome 1q23-25, as is another member of this adhesion family, suggesting that this new family of proteins may be encoded by a cluster of "adhesion protein" loci.
Article|
July 01 1989
Isolation and chromosomal localization of cDNAs encoding a novel human lymphocyte cell surface molecule, LAM-1. Homology with the mouse lymphocyte homing receptor and other human adhesion proteins.
T F Tedder
,
T F Tedder
Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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C M Isaacs
,
C M Isaacs
Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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T J Ernst
,
T J Ernst
Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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G D Demetri
,
G D Demetri
Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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D A Adler
,
D A Adler
Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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C M Disteche
C M Disteche
Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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T F Tedder
Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, Massachusetts.
C M Isaacs
Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, Massachusetts.
T J Ernst
Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, Massachusetts.
G D Demetri
Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, Massachusetts.
D A Adler
Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, Massachusetts.
C M Disteche
Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Online Issn: 1540-9538
Print Issn: 0022-1007
J Exp Med (1989) 170 (1): 123–133.
Citation
T F Tedder, C M Isaacs, T J Ernst, G D Demetri, D A Adler, C M Disteche; Isolation and chromosomal localization of cDNAs encoding a novel human lymphocyte cell surface molecule, LAM-1. Homology with the mouse lymphocyte homing receptor and other human adhesion proteins.. J Exp Med 1 July 1989; 170 (1): 123–133. doi: https://doi.org/10.1084/jem.170.1.123
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