Analysis of antibodies present in the serum of melanoma patient FD has shown that they detect a unique tumor epitope present only on the autologous melanoma cell line SK-MEL-131. Previous results had shown that the unique FD epitope is carried on a common glycoprotein of approximately 90 kD, widely expressed on melanoma and a few other cell types. We now show by sequential radioimmunoprecipitation and partial amino acid sequencing that this common molecule is a previously recognized melanoma antigen, originally identified by mouse mAbs, designated gp95 or p97 (and also known as melanotransferrin). Thus, FD is the first of the class I (unique) melanoma antigens that has been characterized and related to a known cell surface molecule.
A unique antigenic epitope of human melanoma is carried on the common melanoma glycoprotein gp95/p97.
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K S Furukawa, K Furukawa, F X Real, L J Old, K O Lloyd; A unique antigenic epitope of human melanoma is carried on the common melanoma glycoprotein gp95/p97.. J Exp Med 1 February 1989; 169 (2): 585–590. doi: https://doi.org/10.1084/jem.169.2.585
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