Recently, we described a murine helper T cell-derived molecule with T cell growth factor activity that is functionally and structurally distinct from IL-2, IL-4, and other known growth factors. This molecule, designated P40, was identified as a glycoprotein capable of supporting antigen-independent growth of certain helper T cell clones. Here, we report the cloning and expression of a cDNA for this new growth factor. The predicted mature protein is a cationic cysteine-rich polypeptide of 14 kD without significant homology to previously sequenced proteins.
Cloning and characterization of a cDNA for a new mouse T cell growth factor (P40).
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J Van Snick, A Goethals, J C Renauld, E Van Roost, C Uyttenhove, M R Rubira, R L Moritz, R J Simpson; Cloning and characterization of a cDNA for a new mouse T cell growth factor (P40).. J Exp Med 1 January 1989; 169 (1): 363–368. doi: https://doi.org/10.1084/jem.169.1.363
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