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Volume 169, Issue 1
1 January 1989
Journal of Experimental Medicine Cover Image for Volume 169, Issue 1
Article| January 01 1989

Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer.

L M Sollid,
L M Sollid
Institute of Transplantation Immunology, National Hospital, University of Oslo, Norway.
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G Markussen,
G Markussen
Institute of Transplantation Immunology, National Hospital, University of Oslo, Norway.
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J Ek,
J Ek
Institute of Transplantation Immunology, National Hospital, University of Oslo, Norway.
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H Gjerde,
H Gjerde
Institute of Transplantation Immunology, National Hospital, University of Oslo, Norway.
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F Vartdal,
F Vartdal
Institute of Transplantation Immunology, National Hospital, University of Oslo, Norway.
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E Thorsby
E Thorsby
Institute of Transplantation Immunology, National Hospital, University of Oslo, Norway.
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Author and Article Information
L M Sollid, G Markussen, J Ek, H Gjerde, F Vartdal, E Thorsby
Institute of Transplantation Immunology, National Hospital, University of Oslo, Norway.
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1989) 169 (1): 345–350.
https://doi.org/10.1084/jem.169.1.345

Typing of DNA from 94 unrelated children with celiac disease (CD) with HLA-DQA1 and -DQB1 allele-specific oligonucleotide probes revealed that all but one (i.e., 98.9%) may share a particular combination of a DQA1 and a DQB1 gene. These genes are arranged in cis position on the DR3DQw2 haplotype and in trans position in DR5DQw7/DR7DQw2 heterozygous individuals. Thus, most CD patients may share the same cis- or trans-encoded HLA-DQ alpha/beta heterodimer.

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