A cytochrome c-specific, MHC-restricted T cell clone with two complete rearrangements of the same V beta 1 gene element was shown to express two different TCR alpha/beta heterodimers. Antipeptide antisera specific for TCR C beta 1 and C beta 2 peptides each immunoprecipitated distinct disulfide-linked cell surface heterodimers. The clone was derived from immunized allogeneic chimeric mice, and displayed multiple Ia specificities, including the ability to recognize antigen in association with both I-Ek and I-Es Ia molecules, as well as alloreactivity to the I-Eb molecule. It will be important to determine whether each receptor contributes independently to the overall specificity of the clone.
Expression of two distinct T cell receptor alpha/beta heterodimers by an antigen-specific T cell clone.
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L A Matis, A Ezquerra, J E Coligan; Expression of two distinct T cell receptor alpha/beta heterodimers by an antigen-specific T cell clone.. J Exp Med 1 December 1988; 168 (6): 2379–2384. doi: https://doi.org/10.1084/jem.168.6.2379
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