The role of the IL-2-IL-2-R pathway in thymocyte differentiation in vivo is unknown. We have examined fetal thymocyte development in vivo, under conditions where all IL-2-R were saturated from day 13 of gestation with anti-IL-2-R mAbs that were previously shown to render mature T cells unable to respond to IL-2. This produced a dramatic change in the composition of developing T cells: thymocytes from day 1 neonatal mice born to anti-IL-2-R-treated mothers did not contain CD4+ or CD8+ single-positive cell populations. In addition, no generation of surface TCR beta chain-expressing T cells or antigen-reactive functional T cells occurred in treated mice. These data suggest that IL-2-IL-2-R interactions provide signals crucial to in vivo intrathymic development of mature T cells.
Essential role of the interleukin 2-interleukin 2 receptor pathway in thymocyte maturation in vivo.
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L Tentori, D L Longo, J C Zuñiga-Pflucker, C Wing, A M Kruisbeek; Essential role of the interleukin 2-interleukin 2 receptor pathway in thymocyte maturation in vivo.. J Exp Med 1 November 1988; 168 (5): 1741–1747. doi: https://doi.org/10.1084/jem.168.5.1741
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