We examined the effects of treatment with rHuTNF on food consumption and body weight in C3H/HeJ mice. rHuTNF was administered intraperitoneally either by injections of 3, 12, or 24 micrograms twice a day or by implantation of osmotic pumps that released 0.75, 3, or 12 micrograms per day. Dose-dependent reductions in both food intake and weight were induced by rHuTNF. However, in spite of continued exposure to rHuTNF, the mice developed a resistance to rHuTNF and resumed their pretreatment food intake and weight. Non-immunological factors may play a role in the development of this tolerance, since it developed rapidly and faded within 2 wk of cessation of exposure to rHuTNF.
Recombinant human tumor necrosis factor induces acute reductions in food intake and body weight in mice.
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S H Socher, A Friedman, D Martinez; Recombinant human tumor necrosis factor induces acute reductions in food intake and body weight in mice.. J Exp Med 1 June 1988; 167 (6): 1957–1962. doi: https://doi.org/10.1084/jem.167.6.1957
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