Previously, we isolated a Vk gene (Humkv325) from a human placenta that encodes RF light chains bearing the PSL2 and PSL3 CRI markers. Here we report the isolation and characterization of a second human Vk gene (Humkv328) that can be used for RF synthesis. This Vk gene probably encodes at least two 6B6.6 CRI+ RF light chains (Les and Pom) from unrelated subjects, and thus may be related to the light chain-associated 6B6.6 CRI.
Isolation and characterization of a light chain variable region gene for human rheumatoid factors.
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P P Chen, D L Robbins, F R Jirik, T J Kipps, D A Carson; Isolation and characterization of a light chain variable region gene for human rheumatoid factors.. J Exp Med 1 December 1987; 166 (6): 1900–1905. doi: https://doi.org/10.1084/jem.166.6.1900
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