Interferon beta 1, an intermediate in the tumor necrosis factor alpha-induced increased MHC class I expression and an autocrine regulator of the constitutive MHC class I expression.

Leeuwenberg, J F; van Damme, J; Jeunhomme, G M; Buurman, W A

doi:10.1084/jem.166.4.1180

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Article| October 01 1987

Interferon beta 1, an intermediate in the tumor necrosis factor alpha-induced increased MHC class I expression and an autocrine regulator of the constitutive MHC class I expression.

J F Leeuwenberg,

J F Leeuwenberg

Department of Surgery, University of Limburg, Maastricht, The Netherlands.

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J van Damme,

J van Damme

Department of Surgery, University of Limburg, Maastricht, The Netherlands.

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G M Jeunhomme,

G M Jeunhomme

Department of Surgery, University of Limburg, Maastricht, The Netherlands.

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W A Buurman

Department of Surgery, University of Limburg, Maastricht, The Netherlands.

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Author and Article Information

J F Leeuwenberg, J van Damme, G M Jeunhomme, W A Buurman

Department of Surgery, University of Limburg, Maastricht, The Netherlands.

Online ISSN: 1540-9538

Print ISSN: 0022-1007

J Exp Med (1987) 166 (4): 1180–1185.

https://doi.org/10.1084/jem.166.4.1180

In conclusion, our observations indicate that the constitutive MHC class I expression is regulated by autocrine production of IFN-beta 1. TNF-alpha acts as an enhancer of the autocrine production of IFN-beta 1, and consequently as an enhancer of the MHC class I expression and viral protection.

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Interferon beta 1, an intermediate in the tumor necrosis factor alpha-induced increased MHC class I expression and an autocrine regulator of the constitutive MHC class I expression.

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