Monoclonal antibodies (mAb) to streptococcal group A carbohydrate (GAC) are encoded by a minimum of two VH, four JH, four V kappa, three J kappa, one V lambda, and one J lambda gene segments. The IdX, IdI-1, and Id5 idiotypic determinants are expressed by anti-GAC mAb and are found on free kappa chains. Each pattern of these determinants is encoded by a distinct V kappa gene segment, apparently without the requirement for a particular J kappa, VH, or JH gene segment, or somatic mutation. In contrast, the binding site-associated idiotypic determinant IdI-3a does not correlate with any single V or J gene segment.
Molecular dissection of the murine antibody response to streptococcal group A carbohydrate.
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C T Lutz, T L Bartholow, N S Greenspan, R J Fulton, W J Monafo, R M Perlmutter, H V Huang, J M Davie; Molecular dissection of the murine antibody response to streptococcal group A carbohydrate.. J Exp Med 1 February 1987; 165 (2): 531–545. doi: https://doi.org/10.1084/jem.165.2.531
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