We report the isolation and purification of the nephritis strain-associated protein (NSAP) first described by Villareal et al. (8). Amino acid analysis, and determination of the first 21 amino-terminal amino acids indicated that this 46 kD protein is a streptokinase. Biochemical analysis confirmed that NSAP could act as a plasminogen activator; immunological investigations indicated that NSAP is antigenically different from streptokinase from group C streptococcus, and possibly represents a unique streptokinase. It is this uniqueness that may contribute to the role of NSAP in the pathogenesis of acute poststreptococcal glomerulonephritis.
Purification and partial characterization of the nephritis strain-associated protein from Streptococcus pyogenes, group A.
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K H Johnston, J B Zabriskie; Purification and partial characterization of the nephritis strain-associated protein from Streptococcus pyogenes, group A.. J Exp Med 1 March 1986; 163 (3): 697–712. doi: https://doi.org/10.1084/jem.163.3.697
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