We have determined the DNA sequence of a gene encoding a thymus leukemia (TL) antigen in the BALB/c mouse, and have more definitively mapped the cloned BALB/c Tla-region class I gene clusters. Analysis of the sequence shows that the Tla gene is less closely related to the H-2 genes than H-2 genes are to one another or to a Qa-2,3-region genes. The Tla gene, 17.3A, contains an apparent gene conversion. Comparison of the BALB/c Tla genes with those from C57BL shows that BALB/c has more Tla-region class I genes, and that one of the genes absent in C57BL is gene 17.3A.
Structure of a gene encoding a murine thymus leukemia antigen, and organization of Tla genes in the BALB/c mouse.
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D A Fisher, S W Hunt, L Hood; Structure of a gene encoding a murine thymus leukemia antigen, and organization of Tla genes in the BALB/c mouse.. J Exp Med 1 August 1985; 162 (2): 528–545. doi: https://doi.org/10.1084/jem.162.2.528
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