The restriction enzyme Eco RI reveals DNA cleavage sites that serve to distinguish the gene locus believed to encode the beta subunit of the major histocompatibility complex (MHC)-restricted, antigen-specific receptor of the T cell in BALB/c mice from that of SJL/J mice. A monoclonal antibody, KJ16-133, also distinguishes BALB/c and SJL/J, because it recognizes an allotypic marker present on a cell-surface heterodimer believed to function as the MHC-restricted, antigen-specific T cell receptor. This study has shown that these two markers cosegregate in a set of BALB/c X SJL/J recombinant inbred (RI) mouse strains, permitting the conclusion that they are linked to within 3 centimorgans of each other, and to the kappa locus on chromosome 6. The tight linkage between these independently derived, totally different T cell markers substantially strengthens the argument that they characterize the MHC-restricted antigen-specific receptor of the effector T cell.
Article| May 01 1985
Genetic markers of the antigen-specific T cell receptor locus.
Online Issn: 1540-9538
Print Issn: 0022-1007
J Exp Med (1985) 161 (5): 1219–1224.
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R Epstein, N Roehm, P Marrack, J Kappler, M Davis, S Hedrick, M Cohn; Genetic markers of the antigen-specific T cell receptor locus.. J Exp Med 1 May 1985; 161 (5): 1219–1224. doi: https://doi.org/10.1084/jem.161.5.1219
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