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Volume 160, Issue 5
1 November 1984
Journal of Experimental Medicine Cover Image for Volume 160, Issue 5
Article| November 01 1984

A multivalent lacto-N-fucopentaose III-lysyllysine conjugate decompacts preimplantation mouse embryos, while the free oligosaccharide is ineffective.

B A Fenderson,
B A Fenderson
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U Zehavi,
U Zehavi
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S Hakomori
S Hakomori
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Author and Article Information
B A Fenderson
U Zehavi
S Hakomori
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1984) 160 (5): 1591–1596.
https://doi.org/10.1084/jem.160.5.1591

A multivalent lacto-N-fucopentaose (LNFP) III-lysyllysine conjugate was observed to decompact preimplantation mouse embryos. Decompaction was not obtained with free oligosaccharides (LNFP II and III), nor with multivalent LNFP II-lysyllysine or chitotriose-lysyllysine conjugates. These results suggest a role for X hapten recognition during compaction and suggest further that X hapten valency may play a key role in modulating this developmental process.

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