Conventional rabbit antiidiotypic antibodies were raised against a private rabbit anti-tobacco mosaic virus (TMV) idiotype. These rabbit antiidiotypic antibodies were covalently coupled to lipopolysaccharide and then injected into BALB/c mice. As compared with controls, these mice, which have never seen the antigen, synthesized anti-TMV antibodies that are strongly idiotypically cross-reactive with the starting rabbit idiotype. Monoclonal anti-TMV antibodies were prepared from these mice. Furthermore, xenogeneic or syngeneic antiidiotypic antibodies, raised against these monoclonal anti-TMV antibodies, recognized specifically the rabbit idiotype. Rabbit antiidiotypic antibodies alone can induce the same effects, but the concentration of anti-TMV antibodies is lower.
Article| November 01 1984
Induction of anti-tobacco mosaic virus antibodies in mice by rabbit antiidiotypic antibodies.
Online Issn: 1540-9538
Print Issn: 0022-1007
J Exp Med (1984) 160 (5): 1485–1494.
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M Francotte, J Urbain; Induction of anti-tobacco mosaic virus antibodies in mice by rabbit antiidiotypic antibodies.. J Exp Med 1 November 1984; 160 (5): 1485–1494. doi: https://doi.org/10.1084/jem.160.5.1485
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