The highly selective cytotoxicity of site-directed ricin A chain conjugates can be potentiated by membrane-active carboxylic ionophores. The combined use of the two agents results in much faster inactivation of ribosomes and subsequent cell death and lysis. The potency of A chain cytotoxins is correspondingly increased by several orders of magnitude and cells that sparsely express the target antigen or receptor can be killed.
Article| October 01 1984
Carboxylic ionophores enhance the cytotoxic potency of ligand- and antibody-delivered ricin A chain.
Online Issn: 1540-9538
Print Issn: 0022-1007
J Exp Med (1984) 160 (4): 1234–1240.
- Views Icon Views
- PDF LinkPDF
- Share Icon Share
- Search Site
V Raso, J Lawrence; Carboxylic ionophores enhance the cytotoxic potency of ligand- and antibody-delivered ricin A chain.. J Exp Med 1 October 1984; 160 (4): 1234–1240. doi: https://doi.org/10.1084/jem.160.4.1234
Download citation file: