Polyclonal IgA secretion is inducible in murine B cells when DC-T from Peyer's patches (PP) provide the inducing stimulus. PP DC-T, which are composed predominantly of dendritic cells and Lyt-1+ T cells, are capable of dramatic augmentation of IgA secretion by PP or spleen B cells with minimal induction of IgM secretion. DC-T from spleen, however, are incapable of augmenting IgA secretion by either PP or spleen B cells. The level of IgA secretion is dependent upon the dose of DC-T providing the inducing stimulus and reaches a plateau with DC-T:B ratios of less than 1:1. This system for preferential induction of IgA responses should permit elucidation of cellular mechanisms involved in regulation of IgA secretion.
Preferential induction of polyclonal IgA secretion by murine Peyer's patch dendritic cell-T cell mixtures.
D M Spalding, S I Williamson, W J Koopman, J R McGhee; Preferential induction of polyclonal IgA secretion by murine Peyer's patch dendritic cell-T cell mixtures.. J Exp Med 1 September 1984; 160 (3): 941–946. doi: https://doi.org/10.1084/jem.160.3.941
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