Recent studies suggested that the clonally unique Ti epitopes defined by non-cross-reactive monoclonal antibodies might represent the variable regions of the antigen receptor. Here we determine whether such anti-Ti antibodies could trigger clonal T cell activation. Anticlonotypic monoclonal antibodies to the 49/43-kdalton heterodimer of a given clone or antibodies to the 20/25-kdalton membrane associated monomorphic T3 molecule selectively induce proliferation and IL-2 secretion when linked to a solid support. In contrast, anti-T4 and anti-T8 antibodies under the same conditions have no effect. In conclusion, these results imply that anticlonotypic antibody functions in a fashion analogous to antigen and further support the notion that the T3-Ti molecular complex represents the antigen receptor on human T lymphocytes.
Antigen-like effects of monoclonal antibodies directed at receptors on human T cell clones.
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S C Meuer, J C Hodgdon, R E Hussey, J P Protentis, S F Schlossman, E L Reinherz; Antigen-like effects of monoclonal antibodies directed at receptors on human T cell clones.. J Exp Med 1 September 1983; 158 (3): 988–993. doi: https://doi.org/10.1084/jem.158.3.988
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