The transfer of B lymphocytes from mice immunized with type III pneumococcal polysaccharide (SSS-III) results in antigen-specific suppression of the antibody response of recipients immunized with SSS-III. Such suppression shares many features associated with low-dose paralysis, a phenomenon mediated by suppressor T cells; it reaches maximal levels 3 d after the transfer of viable or irradiated immune B cells and can be eliminated by the depletion of SSS-III-binding cells from spleen cell suspensions before transfer. In a two-step cell transfer experiment, purified T lymphocytes, isolated from recipients previously given immune B cells, caused suppression upon transfer to other mice immunized with SSS-III. Also, B-cell-induced suppression could be abrogated in a competitive manner by the infusion of amplifier T lymphocytes, as was previously demonstrated in the case of low-dose paralysis. These findings suggest that B cell surface components, presumably the idiotypic determinants of cell-associated antibody specific for SSS-III, are instrumental in activating suppressor T cells involved in regulating the magnitude of the antibody response to SSS-III.
Activation of antigen-specific suppressor T cells by B cells from mice immunized with type III pneumococcal polysaccharide.
- Views Icon Views
- PDF LinkPDF
- Share Icon Share
- Search Site
C E Taylor, P W Stashak, G Caldes, B Prescott, T E Chused, A Brooks, P J Baker; Activation of antigen-specific suppressor T cells by B cells from mice immunized with type III pneumococcal polysaccharide.. J Exp Med 1 September 1983; 158 (3): 703–717. doi: https://doi.org/10.1084/jem.158.3.703
Download citation file: