In vivo, prolonged polyclonal activation of B cells by the nonantigenic but potent mitogenic lipid A portion of lipopolysaccharide (LPS-R595) resulted in acceleration of the late life systemic lupus erythematosus disease of female MRL/n, BXSB, and NZW mice, mimicking the time, form, and histopathological features characteristic of their early life disease counterparts, i.e., MRL/l females, BXSB males, and (NZB X NZW)F1 females. Similar polyclonal B cell activation of "immunologically normal" mice has less effect and led to a limited expression of autoimmune disease. This R595-induced autoimmunity and immune complex-mediated disease seemed to be the direct result of activation of the immune system and not from other effects of endotoxin since C3H/HeJ, a strain lacking lymphocyte receptors for LPS-R595, had neither serological nor histological evidence of autoimmune disease despite identical treatment.
Induction of murine autoimmune disease by chronic polyclonal B cell activation.
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L Hang, J H Slack, C Amundson, S Izui, A N Theofilopoulos, F J Dixon; Induction of murine autoimmune disease by chronic polyclonal B cell activation.. J Exp Med 1 March 1983; 157 (3): 874–883. doi: https://doi.org/10.1084/jem.157.3.874
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