Delayed-type hypersensitivity (DTH) to phosphorylcholine (PC) could be elicited by mixtures of monoclonal anti-idiotypic antibodies. Using this system in DTH transfers, the question was asked of whether anti-idiotypic antibodies could elicit antigen induced DTH in H-2-incompatible mice. Transfer of PC-activated BALB/c lymph node cells into BALB.K mice and subsequent elicitation with anti-idiotypic antibodies resulted in a positive DTH response. In contrast, elicitation with the antigen PC showed the expected H-2 restriction.
Elicitation of delayed-type hypersensitivity to phosphorylcholine by monoclonal anti-idiotypic antibodies in an allogeneic environment.
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B Arnold, R Wallich, G J Hämmerling; Elicitation of delayed-type hypersensitivity to phosphorylcholine by monoclonal anti-idiotypic antibodies in an allogeneic environment.. J Exp Med 1 August 1982; 156 (2): 670–674. doi: https://doi.org/10.1084/jem.156.2.670
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