Serum samples from 50 Caucasian patients with osteosarcoma were tested for the presence of antibodies to osteosarcoma-associated antigens (OSAA) and typed for nine Gm markers. A highly significant association was found between Gm 3;5,13,14 and unresponsiveness to OSAA, and between 1,3,17;5,13,14,21 and responsiveness to OSAA. These results suggest the existence of complementary immune response genes which in the heterozygous condition permit a response to OSAA.
Heterozygosity at Gm loci associated with humoral immunity to osteosarcoma.
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J P Pandey, B T Shannon, K Y Tsang, H H Fudenberg, J G Camblin; Heterozygosity at Gm loci associated with humoral immunity to osteosarcoma.. J Exp Med 1 April 1982; 155 (4): 1228–1232. doi: https://doi.org/10.1084/jem.155.4.1228
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