An infrequent (2-3%) B lymphocyte subpopulation was found in the normal human tonsil and lymph nodes that shows the phenotypic characteristics of B-chronic lymphocytic leukemia (B-CLL) (rosette formation with mouse erythrocytes, weak expression of membrane Ig, staining for HLA-DR, and OKT1 or Leu-1 detecting a T cell-associated p65 antigen). Preliminary evidence suggests that at least a subpopulation of these cells is found, in small proportions, within the germinal centers. These cells were not observed in the human bone marrow. B-CLL may involve this peripheral B lymphocyte subset.
Article| February 01 1982
Infrequent normal B lymphocytes express features of B-chronic lymphocytic leukemia.
Online Issn: 1540-9538
Print Issn: 0022-1007
J Exp Med (1982) 155 (2): 623–628.
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F Caligaris-Cappio, M Gobbi, M Bofill, G Janossy; Infrequent normal B lymphocytes express features of B-chronic lymphocytic leukemia.. J Exp Med 1 February 1982; 155 (2): 623–628. doi: https://doi.org/10.1084/jem.155.2.623
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