A high proportion of T cell clones derived from bulk cultures selected to M1s a,d determinants were found to have joint specificity for allo-H-2 determinants, and vice versa. Significantly, the patterns of H-2 alloreactivity shown by clones selected to M1sa,b determinants appeared to be random. The possible implications of these findings are discussed.
T cell clones with dual specificity for M1s and various major histocompatibility complex determinants.
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S R Webb, K Molnar-Kimber, J Bruce, J Sprent, D B Wilson; T cell clones with dual specificity for M1s and various major histocompatibility complex determinants.. J Exp Med 1 December 1981; 154 (6): 1970–1974. doi: https://doi.org/10.1084/jem.154.6.1970
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