T cells from strains responder to the antigen poly(Glu40 Ala60) (GA) were depleted of alloreactive cells by bromo-deoxyuridine and light treatment, and were subsequently primed in vitro in GA presented by allogeneic macrophages from nonresponder strains. Antigen-specific secondary proliferative responses restricted by allogeneic Ia molecules of the macrophages were obtained in all strain combinations tested. These data indicate that Ir gene-controlled nonresponsiveness cannot be the result of a failure of antigen presentation.
Responder T cells depleted of alloreactive cells react to antigen presented on allogeneic macrophages from nonresponder strains.
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N Ishii, C N Baxevanis, Z A Nagy, J Klein; Responder T cells depleted of alloreactive cells react to antigen presented on allogeneic macrophages from nonresponder strains.. J Exp Med 1 September 1981; 154 (3): 978–982. doi: https://doi.org/10.1084/jem.154.3.978
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