T cells responsive to macrophages (M phi) in the autologous mixed lymphocyte reaction (AMLR) contain those cells that can be induced to proliferate by soluble antigens. Negative solution (5-bromo-2-deoxyuridine and light) of T cells activated by autologous M phi also removed those cells required for reactivity to Candida albicans and purified protein derivative. Positive selection of T cells responsive to autologous M phi yields a population that is simultaneously enriched in antigen reactivity. Some patients demonstrating cutaneous anergy and diminished in vitro blast transformation in response to soluble antigen also lack T cells responsive to the AMLR to M phi. When considered in conjunction with previously reported data, these findings indicate the AMLR occurring between T cells and M phi in the absence of soluble antigen represents self recognition occurring between antigen-reactive T cells and antigen-presenting M phi.
Article| February 01 1981
Antigen-reactive T cells can be activated buy autologous macrophages in the absence of added antigen.
P B Hausman
D P Stites
J D Stobo
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1981) 153 (2): 476–481.
P B Hausman, D P Stites, J D Stobo; Antigen-reactive T cells can be activated buy autologous macrophages in the absence of added antigen.. J Exp Med 1 February 1981; 153 (2): 476–481. doi: https://doi.org/10.1084/jem.153.2.476
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