Using a monolayer adsorption technique, the fine specificity of cytotoxic effector T lymphocytes (CTL) generated against allogeneic or semi-allogeneic H-2 haplotypes was investigated. The results show that: (a) CTL reacting with the private specificity expressed on an H-2.K molecule can be separated from those reacting with the public specificities expressed on the same molecule and (b) the CTL that recognize cross-reacting H-2 determinants (public specificities) can also be separated into several subpopulations. These data support the hypothesis that an allogeneic stimulation induces a large number of independent T cell clones that react with H-2 determinants.
Article| March 01 1980
Separate cytotoxic T lymphocyte subsets recognize the different H-2 specificities.
J Exp Med (1980) 151 (3): 773–780.
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A Vazquez, C Néauport-Sautès, A Senik; Separate cytotoxic T lymphocyte subsets recognize the different H-2 specificities.. J Exp Med 1 March 1980; 151 (3): 773–780. doi: https://doi.org/10.1084/jem.151.3.773
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