The laboratory recombinant haplotype H-1acl of the Norway rat has been used in studies of the rejection and passive enhancement of kidney allografts. While the full H-1a haplotype provoked acute rejection, neither of the isolated subregions, H-1Aa and H-1Ba, did so. It was also found that alloantisera raised against either the H-1Aa or the H-1Ba antigens would enhance the grafts. It is suggested that both MHC subregions contain a histocompatibility locus (i) for kidney (as they do for skin) and that in the genetic combinations studied only incompatibility for both provokes a response sufficient for rejection. In other combinations, however, single region incompatibilities may be sufficient.
The role of subregions of the rat major histocompatibility complex in the rejection and passive enhancement of renal allografts.
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G G Gallico, G W Butcher, J C Howard; The role of subregions of the rat major histocompatibility complex in the rejection and passive enhancement of renal allografts.. J Exp Med 1 January 1979; 149 (1): 244–253. doi: https://doi.org/10.1084/jem.149.1.244
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