The immunochemical analysis of Daudi Ia molecules by a variety of alloantisera led to the recognition of at least three molecular species carrying different antigenic determinants: DRw6, DC-1, and DC-2. Genetic as well as structural evidence indicates that DRw6 and DC-1 molecules are controlled by separate, HLA-linked loci, rather than by alleles at the same locus. The alloantigenic determinants appear to be expressed on the small Ia subunit. DC-1 and DC-2 determinants discussed had not been defined by serological analysis at the population level, but were demonstrated to be present by immunochemical analysis at the molecular level.
Article| December 01 1978
Immunological dissection of human Ia molecules.
G B Ferrara
Online Issn: 1540-9538
Print Issn: 0022-1007
J Exp Med (1978) 148 (6): 1592–1611.
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R Tosi, N Tanigaki, D Centis, G B Ferrara, D Pressman; Immunological dissection of human Ia molecules.. J Exp Med 1 December 1978; 148 (6): 1592–1611. doi: https://doi.org/10.1084/jem.148.6.1592
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