The nature of the cells required for first-set graft rejection in vivo was examined by using an adoptive transfer system to restore heart-graft rejection in irradiated rats. Highly purified inocula of peripheral T lymphocytes were shown to quantitatively account for the restorative ability of adoptively transferred cells. These T cells were shown to be long-lived small lymphocytes which are not recently derived from the thymus during adult life. They belong to the pool of T cells which constantly recirculate from blood to lymph as shown by their rapid appearance in the lymph of iradiated syngeneic rats after intravenous injection. Neither B lymphocytes nor antibodies in the circulation or in the graft itself are required for first-set graft rejection.
The cellular basis of allograft rejection in vivo. I. The cellular requirements for first-set rejection of heart grafts.
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B M Hall, S Dorsch, B Roser; The cellular basis of allograft rejection in vivo. I. The cellular requirements for first-set rejection of heart grafts.. J Exp Med 1 October 1978; 148 (4): 878–889. doi: https://doi.org/10.1084/jem.148.4.878
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