Abelson murine leukemia virus (A-MuLV)-transformed fibroblast nonproducer cells were used to prepare A-MuLV stocks containing a number of different helper viruses. The oncogenicity of the A-MuLV stocks was tested by animal inoculation and their ability to transform normal mouse bone marrow cells was measured in vitro. All of the A-MuLV stocks transformed fibroblast cells efficiently. However, only A-MuLV stocks prepared with helper viruses that are highly oncogenic were efficient in vivo and in vitro in hematopoietic cell transformation. In addition, inefficient helpers did not establish a stable infection in lymphoid nonproducer cells. Thus, helper virus has a more central role in lymphoid cell transformation than in fibroblast cell transformation.
Article| April 01 1978
The effect of helper virus on Abelson virus-induced transformation of lymphoid cells.
Online Issn: 1540-9538
Print Issn: 0022-1007
J Exp Med (1978) 147 (4): 1126–1141.
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N Rosenberg, D Baltimore; The effect of helper virus on Abelson virus-induced transformation of lymphoid cells.. J Exp Med 1 April 1978; 147 (4): 1126–1141. doi: https://doi.org/10.1084/jem.147.4.1126
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