A new lymphocyte-activating determinant (Lad) locus expressed on T cells was identified, mapping in the I-C subregions of H-2k and H-2d haplotypes. The mixed lymphocyte reaction stimulation could be inhibited by anti-Ia sera made in strains incompatible for this chromosomal segment. Experiments with purified lymphocyte cell populations suggested that this Lad locus was expressed on T cells. Further, only purified T cells were able to remove the inhibiting activity from the anti-Ia sera. I-C subregion gene(s) seem to code for products selectively expressed on a subpopulation of T cells.
Article| April 01 1978
A new lymphocyte-activating determinant locus expressed on T cells, and mapping in I-C subregion.
C S David
Online Issn: 1540-9538
Print Issn: 0022-1007
J Exp Med (1978) 147 (4): 1028–1037.
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K Okuda, C S David; A new lymphocyte-activating determinant locus expressed on T cells, and mapping in I-C subregion.. J Exp Med 1 April 1978; 147 (4): 1028–1037. doi: https://doi.org/10.1084/jem.147.4.1028
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