Purified populations of both human peripheral blood monocytes and murine peritoneal macrophages synthesize and release Prostaglandin E in vitro. In contrast, prostaglandin E was detected in neither the supernate fluids from cultures of highly enriched human lymphocytes and granulocytes, nor in nonadherent murine peritoneal cells. Macrophage prostaglandin E production was markedly enhanced by endotoxin, and completely suppressed by indomethacin. All neoplastic monocyte-macrophage cell lines examined elaborated prostaglandin E in vitro, either constitutively or after induction with endotoxin. In contrast, prostaglandin E production could not be detected from either a T- or B-cell lymphoma, whether or not they were treated with endotoxin. These findings thus indicate that the blood monocyte and tissue macrophage represent an important source of prostaglandin E, a function shared by both normal and neoplastic mononuclear phagocytes.
Article| March 01 1978
Prostaglandin E production by human blood monocytes and mouse peritoneal macrophages.
J I Kurland
Online Issn: 1540-9538
Print Issn: 0022-1007
J Exp Med (1978) 147 (3): 952–957.
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J I Kurland, R Bockman; Prostaglandin E production by human blood monocytes and mouse peritoneal macrophages.. J Exp Med 1 March 1978; 147 (3): 952–957. doi: https://doi.org/10.1084/jem.147.3.952
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