The ability of female mice to rapidly reject syngenic male skin grafts is largely determined by dominant genes in the IB region of the H-2b halotype, whereas the ability to produce anti-H-Y cytotoxic cells is determined by a dominant gene in the IA region the H-2b halotype, or by complementary genes in the IC region of some other haplotypes. Thus, it seems that H-2-retricted anti-H-Y cytotoxic T cells are not responsible for the rejection of syngeneic male skin grafts.
Cytotoxic T-cell responses to H-Y: correlation with the rejection of syngeneic male skin grafts.
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M Hurme, P R Chandler, C M Hetherington, E Simpson; Cytotoxic T-cell responses to H-Y: correlation with the rejection of syngeneic male skin grafts.. J Exp Med 1 March 1978; 147 (3): 768–775. doi: https://doi.org/10.1084/jem.147.3.768
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