Anomalous appearance of TL (thymus-leukemia) antigens is a characteristic feature of radiation-induced leukemias of C57bl/6 mice. We now report that thymocytes of irradiated C57BL/6 mice express TL antigens long before the development of overt leukemia. Thus, TL is a marker for preleukemic changes occurring during radiation leukemogenesis. Low levels of murine leukemia virus (MuLV)-related antigens are also detected on preleukemic thymocytes. Comparative tests on individual mice show no direct correlation between TL and MuLV antigen expression.
Article| July 01 1977
Preleukemic expression of TL antigens in x-irradiated C57BL/6 mice.
L J Old
J Exp Med (1977) 146 (1): 271–276.
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E Stockert, L J Old; Preleukemic expression of TL antigens in x-irradiated C57BL/6 mice.. J Exp Med 1 July 1977; 146 (1): 271–276. doi: https://doi.org/10.1084/jem.146.1.271
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